Dot Porter, Curator, Digital Research Services at the University of Pennsylvania Library, offers a video orientation to Penn Library’s LJS 225, Litterarum simulationis liber, by Michael Zopello. This manuscript was written in Rome between 1455 and 1458, in Latin and Italian. It was a presentation copy for Pope Callistus III of a work on cryptography that describes two systems: in the first, Italian words beginning with one letter are all represented by Italian words beginning with another letter; in the second, signs or symbols represent letters or entire Italian words (titles, city names, and numbers).
See the full online facsimile of this work in Penn in Hand.